Particularly Hazard Substance Drug

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To find a drug identified in GUMC's Particularly Hazardous Substance (PHS) list, use the search field to enter the drug name (case-sensitive). Drugs not found on the list, yet having special acute or chronic hazards (e.g., carcinogenecity, teratogenecity), require development of an SOP. Contact EH&S for assistance.

 

Drug AHFS classification Reason for listing Links
abacavir* 8:18.08.20 nucleoside and reverse transcriptase inhibitors FDA Pregnancy Category C; malignant tumors observed in male and female mice and rats; genotoxic in in vivo micronucleus test. DailyMed; DrugBank
abiraterone* 10:00 antineoplastic agents Women who are pregnant or women who may be pregnant should not handle without protection (e.g., gloves); FDA Pregnancy Category X DailyMed; DrugBank
acitretin 88:04 vitamin A Black Box warning on adverse reproductive effects; FDA Pregnancy Category X DailyMed; DrugBank
ado- trastuzumab emtansine 10:00 antineoplastic agents Conjugated monoclonal antibody; FDA Pregnancy Category D DailyMed; DrugBank
alefacept 84:92 skin and mucous membrane agents, miscel- laneous Increased frequency of malignancies observed in treated patients; FDA Preg- nancy Category B DailyMed; DrugBank
alitretinoin 84:92 skin and mucous membrane agents, miscel- laneous FDA Pregnancy Category D DailyMed; DrugBank
altretamine 10:00 antineoplastic agents FDA Pregnancy category D DailyMed; DrugBank
ambrisentan 24:12:92 vasodilating agents, miscellaneous Black Box warning on adverse reproductive effects; reduced sperm counts in patients; FDA Pregnancy Category X DailyMed;
amsacrine NA antineoplastic agents IARC Group 2B DrugBank
anastrozole 10:00 antineoplastic agents FDA Pregnancy category X DailyMed; DrugBank
apomorphine 28:36.20.08 Nonergot- derivative dopamine receptor agonists FDA Pregnancy Category C; genotoxic in several in vitro assays. DailyMed; DrugBank
arsenic trioxide 10:00 antineoplastic agents IARC Group 1 carcinogen**; FDA Pregnancy Category D DailyMed; DrugBank
azacitidine 10:00 antineoplastic agents IARC Group 2A carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
azathioprine 92:44 immunosuppressant agents IARC Group 1 carcinogen**; FDA Pregnancy Category D*** DailyMed; DrugBank
bacillus calmette Guerin (BCG)*** 80:12 vaccines See special handling requirements**; FDA Preg- nancy Category C DailyMed
bendamustine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed;
bexarotene 10:00 antineoplastic agents FDA Pregnancy Category X DailyMed; DrugBank
bicalutimide 10:00 antineoplastic agents FDA Pregnancy Category X DailyMed; DrugBank
bleomycin 10:00 antineoplastic agents IARC Group 2B; FDA Preg- nancy Category D DailyMed; DrugBank
bortezomib 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
bosentan 24:12:92 vasodilating agents, miscellaneous Black Box warning on adverse reproductive effects; FDA Pregnancy Category X DailyMed; DrugBank
brentuximab vedotin 10:00 antineoplastic agents Conjugated monoclonal antibody; FDA Pregnancy Category D DailyMed; DrugBank
busulfan 10:00 antineoplastic agents IARC Group 1 carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
cabazitaxel 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
cabergoline 28:36:20:04 ergot-derivative dopamine receptor agonists Inhibition of conception and embryo fetal effects at doses below recommended human dose; FDA Pregnancy Cate- gory B DailyMed; DrugBank
capecitabine 10:00 antineoplastic agents Metabolized to 5-fluoro- uracil; FDA Pregnancy Cate- gory D DailyMed; DrugBank
carbamazepine 28:12:92 anticonvulsants, miscellaneous Black Box warning for aplastic anemia; congenital malformations in offspring of mothers who took drug; rapid transplacental passage; FDA Pregnancy DailyMed; Drugbank
carboplatin 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
carmustine 10:00 antineoplastic agents IARC Group 2A carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
cetrorelix 92:40 gonadotropin- releasing hormone anago- nists FDA Pregnancy Category X DailyMed; DrugBank
chlorambucil 10:00 antineoplastic agents IARC Group 1 carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
chloramphenicol 8:12:08 chloramphenicols IARC Group 2A carcinogen; FDA Pregnancy Category C DailyMed; DrugBank
choriogonado- tropin 68:18 gonadotropins FDA pregnancy Category X; may cause fetal harm when administered to a pregnant woman. DailyMed; DrugBank
cidofovir 8:18:32 nucleoside and nucleotides FDA Pregnancy Category C DailyMed; Drugbank
cisplatin 10:00 antineoplastic agents IARC Group 2A carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
cladribine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
clofarabine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
clonazepam 28:12:08 benzodiapines Increased risk of congenital abnormalities when taken in first trimester; FDA Pregnancy Category D DailyMed; DrugBank
colchicine 92:16 antigout agents FDA Pregnancy Category C; published animal reproduc- tion and development studies indicate it causes embryofetal toxicity, teratogenicity, and altered postnatal develop- ment at exposures within or above the clinical therapeutic range DailyMed; DrugBank
crizotinib 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed
cyclophospha- mide 10:00 antineoplastic agents IARC Group 1 carcinogen; FDA Pregnancy Category D DailyMed; Drugbank
cyclosporine 92:44 immunosuppressive agents IARC Group 1 carcinogen; FDA pregnancy Category C DailyMed; Drugbank
cytarabine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
dacarbazine 10:00 antineoplastic agents FDA Pregnancy Category C DailyMed; Drugbank
dactinomycin 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
dasatinib 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; Drugbank
daunorubicin 10:00 antineoplastic agents IARC Group 2B, AKA dauno- mycin; FDA Pregnancy Cat- egory D DailyMed; Drugbank
decitabine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; Drugbank
deferiprone 64:00 Heavy metal antagonists Genotoxic in vitro and in vivo; FDA Pregnancy DailyMed; DrugBank
degarelix 10:00 antineoplastic agents FDA Pregnancy Category X DailyMed; Drugbank
dexrazoxane 92:56 protective agents FDA Pregnancy Category C; secondary malignancies observed in patients treated long term with Razoxane (a racemic mixture containing dexrazane); genotoxic in vitro and in vivo; in labo- ratory studies, testicular atrophy observed at or below the human dose DailyMed; DrugBank
diethylstilbestrol NA IARC Group 1 carcinogen; FDA Pregnancy Category X DrugBank
dinoprostone 76:00 oxytocics Hazardous only for women in late pregnancy; FDA Preg- nancy Category C DailyMed; DrugBank
divalproex 28:12:92 anticonvulsants, miscellaneous Black Box warning for tera- togenicity; FDA Pregnancy Category D; tumors seen in laboratory studies at doses below MRHD DailyMed
docetaxel 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
doxorubicin 10:00 antineoplastic agents IARC Group 2A carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
dronedarone 24:04:04 antiarrythmics Teratogenic in laboratory studies at ½ MRHD; FDA Preg- nancy Category X DailyMed; DrugBank
dutasteride 92:08 5-alpha reductase inhibitors Women warned not to handle; FDA Pregnancy Cate- gory X DailyMed; DrugBank
entecavir 8:18:32 nucleosides and nucleotides FDA Pregnancy Category C DailyMed; DrugBank
epirubicin 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; Drugbank
ergonovine/meth- ylergonovine 76:00 oxytocics Use is contraindicated during pregnancy because of its uterotonic effects; FDA Preg- nancy Category C DailyMed; DrugBank; DrugBank
eribulin 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
erlotinib 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
estradiol 68:16:04 estrogens   DailyMed; DrugBank
estramustine 10:00 antineoplastic agents FDA Pregnancy Category X DailyMed; Drugbank
estrogen/ progesterone combinations 68:12 contraceptives   DailyMed
estrogens, conjugated 68:16:04 estrogens   DailyMed
estrogens, esterified 68:16:04 estrogens   DailyMed
estropipate 68:16:04 estrogens   DailyMed; DrugBank
etoposide 10:00 antineoplastic agents IARC Group 1 carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
everolimus 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; Drugbank
exemestane 10:00 antineoplastic agents FDA Pregnancy Category X DailyMed; DrugBank
finasteride 92:08 5-alpha reductase inhibitors Women should not handle crushed or broken finasteride tablets when they are preg- nant or may potentially be pregnant due to potential risk to a male fetus; FDA Preg- nancy Category X DailyMed; Drugbank
fingolimod 92:20 biologic response modifiers   DailyMed; DrugBank
floxuridine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
fluconazole 8:18.08 azoles FDA Pregnancy Category C; case reports describe con- genital anomalies in infants exposed in utero to maternal fluconazole (400-800 mg/ day) during most or all of the first trimester, similar to those seen in animal studies DailyMed; DrugBank
fludarabine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
fluorouracil 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
fluoxymesterone 68:08 androgens Tumors in mice and rats and possibly humans; FDA Preg- nancy Category X DailyMed; DrugBank
flutamide 10:00 antineoplastic agents Indicated only for men; FDA Pregnancy Category D DailyMed; DrugBank
fosphenytoin 28:12.12 hydantoins Metabolized to phenytoin; FDA Pregnancy Category D DailyMed; DrugBank
fulvestrant 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
ganciclovir 8:18:32 nucleosides and nucleotides FDA Pregnancy Category C DailyMed; DrugBank
ganirelix 92:40 gonadotropin- eleasing hormone antagonists FDA Pregnancy Category X DailyMed
gemcitabine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
gemtuzumab ozogamicin 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
gonadotropin, chorionic 68:18 gonadotropins Defects of forelimbs and central nervous system and alterations in sex ratio have been reported in laboratory studies; FDA pregnancy Cat- egory C DailyMed; DrugBank7
goserelin 10:00 antineoplastic agents FDA Pregnancy Category X DailyMed; Drugbank
hydroxyurea 10:00 antineoplastic agents Special warning on handling bottles and capsules DailyMed; DrugBank
icatibant 92:32 complement inhibitors FDA Pregnancy Category C; in laboratory studies, prema- ture birth and abortion rates increased at a dose that was less than 1/40th the MRHD and delayed parturition and fetal death occurred at 0.5 and 2-fold, respectively, the MRHD DailyMed; DrugBank
idarubicin 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
ifosfamide 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
imatinib 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
irinotecan 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
ixabepilone 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
leflunomide 92:36 disease-modifying antirheumatic agents Teratogenic in laboratory studies at 1/10 HD; marked postnatal survival at 1/100 HD; FDA Pregnancy Cate- gory X; severe liver injury reported in patients; carcino- genicity observed at doses below HD DailyMed; DrugBank
lenalidomide 92:20 biologic response modulators Analog of thalidomide; FDA Black box warnings for limb abnormalaties; pregnancy Cat- egory X; in laboratory studies, caused thalidomide-type limb defects in monkey offspring DailyMed; DrugBank
letrozole 10:00 antineoplastic agents FDA pregnancy Category X DailyMed; DrugBank
leuprolide 10:00 antineoplastic agents FDA Pregnancy Category X DailyMed; Drugbank
liraglutide recombinant 68:20.06 incretin mimetics FDA Pregnancy Category C; Black Box warning for thy- roid C-cell tumors, with supporting evidence in lab- oratory studies; also in labo- ratory studies, teratogenic at or below the MRHD. DailyMed; DrugBank
lomustine 10:00 antineoplastic agents IARC Group 2A carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
mechloreth- amine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
medroxyproges- terone acetate 68:32 progestins IARC Group 2B; FDA Preg- nancy Category X DailyMed; DrugBank
megestrol 10:00 antineoplastic agents Nursing should be dis- continued if megestrol is required. Women at risk of pregnancy should avoid exposure; FDA Pregnancy Category X DailyMed; DrugBank
melphalan 10:00 antineoplastic agents IARC Group 1 carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
mentropins 68:18 gonadotropins FDA Pregnancy Category X Drugbank
mercaptopurine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
methotrexate 10:00 antineoplastic agents FDA Pregnancy Category X DailyMed; DrugBank
methyltestos- terone 68:08 androgens FDA Pregnancy Category X DailyMed; DrugBank
mifepristone 76:00 oxytocics When given to pregnant women results in termination of pregnancy; FDA Pregnancy Category X DailyMed; DrugBank
misoprostol 56:28.28 prostaglandins FDA Pregnancy Category X DailyMed; DrugBank
mitomycin 10:00 antineoplastic agents IARC Group 2B; FDA Preg- nancy Category D DailyMed; DrugBank
mitotane 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
mitoxantrone 10:00 antineoplastic agents IARC Group 2B; FDA Preg- nancy Category D DailyMed; DrugBank
mycophenolate mofetil 92:44 immunosuppressive agents   DailyMed; DrugBank
mycophenolic acid 92:44 immunosuppressive agents   DailyMed; DrugBank
nafarelin 68:18 gonadotropins Note: Given only as nasal spray; no potential for occu- pational exposure; FDA Preg- nancy Category X DailyMed; DrugBank
nelarabine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
nevirapine 8:18.08.16 nonnucleoside reverse transcriptase inhibitors   DailyMed; DrugBank
nilotinib 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
omacetaxin 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
oxaliplatin 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
oxcarbazepine 28:12:92 anticonvulsants, miscellaneous   DailyMed; Drugbank
oxytocin 76:00 oxytocics Hazardous only for women in 3rd trimester; FDA Pregnancy Category C DailyMed; DrugBank
paclitaxel 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
palifermin 84:16 cell stimulants and proliferants   DailyMed; Drugbank
paroxetine 28:16:04:20 selective sero- tonin uptake inhibitors Increased risk of congenital abnormalities when taken in first trimester; complications in pregnancy when taken in third trimester; FDA Preg- nancy Category D DailyMed; Drugbank
pazopanib 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
pemetrexed 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
pentetate calcium trisodium NA Severe teratogenic effects in laboratory studies in dogs: supplied in ampule which can lead to occupational exposure; FDA Pregnancy Category C DailyMed
pentostatin 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
phenoxyben- zamine 12:16:04:04 non-selective alpha-andrenergic blocking agents   DailyMed; DrugBank
phenytoin 28:12.12 hydantoins   DailyMed; DrugBank
pipobroman NA   Drugbank
plerixafor 20:16 hematopoietic agents Teratogenic in laboratory studies; FDA Pregnancy Cate- gory D DailyMed; DrugBank
pralatrexate 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
procarbazine 10:00 antineoplastic agents IARC Group 2A carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
progesterone 68:32 progestins   DailyMed; Drugbank
progestins 68:12 contraceptives    
propylthiouracil 68:36.08 antithyroid agents   DailyMed; DrugBank
raloxifene 68:16:12 estrogen ago- nists-antagonists   DailyMed; Drugbank
rasagiline 28:36 antiparkinsonian agents   DailyMed; Drugbank
ribavirin 8:18:32 nucleosides and nucleotides Teratogenic and embryotoxic effects in several laboratory studies; contraindicated in women who are pregnant and in the male partners of women who are pregnant; FDA Pregnancy Category X DailyMed; DrugBank
risperidone 28:16:08:04 atypical anti- psychotics   DailyMed; DrugBank
romidepsin 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed
sirolimus 92:44 immunosuppressive agents   DailyMed; DrugBank
sorafenib 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
spironolactone 24:32.20 mineralocorticoid receptor antagonists FDA Pregnancy Category C; black box warning for tumorogenicity in laboratory studies. DailyMed; DrugBank
streptozocin 10:00 antineoplastic agents IARC Group 2B; FDA Preg- nancy Category D DailyMed; DrugBank
sunitinib 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
tacrolimus 92:44 immunosuppressive agents Increased risk of lymphomas and other malignancies; reproductive effects seen in laboratory studies below the MRHD; excreted in breast milk; FDA Pregnancy Cate- gory C DailyMed; DrugBank
tamoxifen 10:00 antineoplastic agents IARC Group 1 carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
telavancin 8:12:28 glycopeptides Black Box warning for poten- tial risk to fetus and adverse reproductive outcomes; reduced fetal weights and increased rates of digit and limb malformations in three species at clinical doses; FDA Pregnancy Category C DailyMed; Drugbank
temozolomide 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
temsirolimus 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
teniposide 10:00 antineoplastic agents IARC Group 2A carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
testosterone 68:08 androgens Children should avoid contact with unwashed or unclothed application sites on skin; FDA Pregnancy Category X DailyMed; DrugBank
thalidomide 92:20 biologic response modulators FDA Pregnancy Category X DailyMed; DrugBank
thioguanine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
thiotepa 10:00 antineoplastic agents IARC Group 1 carcinogen; FDA Pregnancy Category D DailyMed; DrugBank
topiramate 28:12.92 anticonvulsants, miscellaneous FDA Pregnancy Category D DailyMed; DrugBank
topotecan 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
toremifene 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
tretinoin 84:16 cell stimulants and proliferants Black Box warning for severe birth defects; Special FDA dis- tribution system; FDA Preg- nancy Category X DailyMed; DrugBank
trimetrexate 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
triptorelin 10:00 antineoplastic agents FDA Pregnancy Category X DailyMed
ulipristal 68:12 contraceptives FDA Pregnancy Category X DailyMed
uracil mustard NA FDA Pregnancy Category D DrugBank
valganciclovir 8:18:32 nucleosides and nucleotides FDA Pregnancy Category C DailyMed; DrugBank
valproate/valproic acid 28:12:92 anticonvulsants, miscellaneous Black Box warning for terato- genicity; congenital malfor- mations including neural tube defects and others; terato- genic in multiple species; FDA Pregnancy Category D DailyMed; DailyMed; DrugBank
valrubicin 10:00 antineoplastic agents FDA Pregnancy Category C DailyMed; DrugBank
vandetanib 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
vemurafenib 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
vigabatrin 28:12:92 anticonvulsants, miscellaneous Malformations seen in labora- tory studies below the MRHD; FDA Pregnancy Category C DailyMed; Drugbank
vinblastine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
vincristine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; Drugbank
vinorelbine 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; DrugBank
voriconazole 8:14.08 azoles FDA Pregnancy Category D DailyMed; DrugBank
vorinostat 10:00 antineoplastic agents FDA Pregnancy Category D DailyMed; Drugbank
warfarin 20:12.04.08 coumarin derivatives FDA Pregnancy Category D DailyMed; DrugBank
zidovudine 8:18:08 antiretroviral agents IARC Group 2B; FDA Preg- nancy Category C DailyMed; DrugBank
ziprasidone 28:16:08:04 atypical antipsychotics Developmental toxicity, including possible terato- genic effects at doses similar to human therapeutic doses; an increase in the number DailyMed; Drugbank
zoledronic acid 92:24 bone resorption inhibitors Number of stillbirths increased and survival of neo- nates decreased in laboratory studies at low doses; FDA Pregnancy Category D DailyMed; DrugBank
zonisamide 28:12:92 anticonvulsants, miscellaneous Teratogenic in multiple animal species; FDA Preg- nancy Category C DailyMed; DrugBank