Particularly Hazard Substance Drug

Drug

AHFS classification

Reason for listing

Links

abacavir*

8:18.08.20 nucleoside and reverse transcriptase inhibitors

FDA Pregnancy Category C; malignant tumors observed in male and female mice and rats; genotoxic in in vivo micronucleus test.

DailyMed; DrugBank

abiraterone*

10:00 antineoplastic agents

Women who are pregnant or women who may be pregnant should not handle without protection (e.g., gloves); FDA Pregnancy Category X

DailyMed; DrugBank

acitretin

88:04 vitamin A

Black Box warning on adverse reproductive effects; FDA Pregnancy Category X

DailyMed; DrugBank

ado- trastuzumab emtansine

10:00 antineoplastic agents

Conjugated monoclonal antibody; FDA Pregnancy Category D

DailyMed; DrugBank

alefacept

84:92 skin and mucous membrane agents, miscel- laneous

Increased frequency of malignancies observed in treated patients; FDA Preg- nancy Category B

DailyMed; DrugBank

alitretinoin

84:92 skin and mucous membrane agents, miscel- laneous

FDA Pregnancy Category D

DailyMed; DrugBank

altretamine

10:00 antineoplastic agents

FDA Pregnancy category D

DailyMed; DrugBank

ambrisentan

24:12:92 vasodilating agents, miscellaneous

Black Box warning on adverse reproductive effects; reduced sperm counts in patients; FDA Pregnancy Category X

DailyMed;

amsacrine

NA antineoplastic agents

IARC Group 2B

DrugBank

anastrozole

10:00 antineoplastic agents

FDA Pregnancy category X

DailyMed; DrugBank

apomorphine

28:36.20.08 Nonergot- derivative dopamine receptor agonists

FDA Pregnancy Category C; genotoxic in several in vitro assays.

DailyMed; DrugBank

arsenic trioxide

10:00 antineoplastic agents

IARC Group 1 carcinogen**; FDA Pregnancy Category D

DailyMed; DrugBank

azacitidine

10:00 antineoplastic agents

IARC Group 2A carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

azathioprine

92:44 immunosuppressant agents

IARC Group 1 carcinogen**; FDA Pregnancy Category D***

DailyMed; DrugBank

bacillus calmette Guerin (BCG)***

80:12 vaccines

See special handling requirements**; FDA Preg- nancy Category C

DailyMed

bendamustine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed;

bexarotene

10:00 antineoplastic agents

FDA Pregnancy Category X

DailyMed; DrugBank

bicalutimide

10:00 antineoplastic agents

FDA Pregnancy Category X

DailyMed; DrugBank

bleomycin

10:00 antineoplastic agents

IARC Group 2B; FDA Preg- nancy Category D

DailyMed; DrugBank

bortezomib

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

bosentan

24:12:92 vasodilating agents, miscellaneous

Black Box warning on adverse reproductive effects; FDA Pregnancy Category X

DailyMed; DrugBank

brentuximab vedotin

10:00 antineoplastic agents

Conjugated monoclonal antibody; FDA Pregnancy Category D

DailyMed; DrugBank

busulfan

10:00 antineoplastic agents

IARC Group 1 carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

cabazitaxel

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

cabergoline

28:36:20:04 ergot-derivative dopamine receptor agonists

Inhibition of conception and embryo fetal effects at doses below recommended human dose; FDA Pregnancy Cate- gory B

DailyMed; DrugBank

capecitabine

10:00 antineoplastic agents

Metabolized to 5-fluoro- uracil; FDA Pregnancy Cate- gory D

DailyMed; DrugBank

carbamazepine

28:12:92 anticonvulsants, miscellaneous

Black Box warning for aplastic anemia; congenital malformations in offspring of mothers who took drug; rapid transplacental passage; FDA Pregnancy

DailyMed; Drugbank

carboplatin

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

carmustine

10:00 antineoplastic agents

IARC Group 2A carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

cetrorelix

92:40 gonadotropin- releasing hormone anago- nists

FDA Pregnancy Category X

DailyMed; DrugBank

chlorambucil

10:00 antineoplastic agents

IARC Group 1 carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

chloramphenicol

8:12:08 chloramphenicols

IARC Group 2A carcinogen; FDA Pregnancy Category C

DailyMed; DrugBank

choriogonado- tropin

68:18 gonadotropins

FDA pregnancy Category X; may cause fetal harm when administered to a pregnant woman.

DailyMed; DrugBank

cidofovir

8:18:32 nucleoside and nucleotides

FDA Pregnancy Category C

DailyMed; Drugbank

cisplatin

10:00 antineoplastic agents

IARC Group 2A carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

cladribine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

clofarabine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

clonazepam

28:12:08 benzodiapines

Increased risk of congenital abnormalities when taken in first trimester; FDA Pregnancy Category D

DailyMed; DrugBank

colchicine

92:16 antigout agents

FDA Pregnancy Category C; published animal reproduc- tion and development studies indicate it causes embryofetal toxicity, teratogenicity, and altered postnatal develop- ment at exposures within or above the clinical therapeutic range

DailyMed; DrugBank

crizotinib

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed

cyclophospha- mide

10:00 antineoplastic agents

IARC Group 1 carcinogen; FDA Pregnancy Category D

DailyMed; Drugbank

cyclosporine

92:44 immunosuppressive agents

IARC Group 1 carcinogen; FDA pregnancy Category C

DailyMed; Drugbank

cytarabine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

dacarbazine

10:00 antineoplastic agents

FDA Pregnancy Category C

DailyMed; Drugbank

dactinomycin

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

dasatinib

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; Drugbank

daunorubicin

10:00 antineoplastic agents

IARC Group 2B, AKA dauno- mycin; FDA Pregnancy Cat- egory D

DailyMed; Drugbank

decitabine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; Drugbank

deferiprone

64:00 Heavy metal antagonists

Genotoxic in vitro and in vivo; FDA Pregnancy

DailyMed; DrugBank

degarelix

10:00 antineoplastic agents

FDA Pregnancy Category X

DailyMed; Drugbank

dexrazoxane

92:56 protective agents

FDA Pregnancy Category C; secondary malignancies observed in patients treated long term with Razoxane (a racemic mixture containing dexrazane); genotoxic in vitro and in vivo; in labo- ratory studies, testicular atrophy observed at or below the human dose

DailyMed; DrugBank

diethylstilbestrol

NA

IARC Group 1 carcinogen; FDA Pregnancy Category X

DrugBank

dinoprostone

76:00 oxytocics

Hazardous only for women in late pregnancy; FDA Preg- nancy Category C

DailyMed; DrugBank

divalproex

28:12:92 anticonvulsants, miscellaneous

Black Box warning for tera- togenicity; FDA Pregnancy Category D; tumors seen in laboratory studies at doses below MRHD

DailyMed

docetaxel

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

doxorubicin

10:00 antineoplastic agents

IARC Group 2A carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

dronedarone

24:04:04 antiarrythmics

Teratogenic in laboratory studies at ½ MRHD; FDA Preg- nancy Category X

DailyMed; DrugBank

dutasteride

92:08 5-alpha reductase inhibitors

Women warned not to handle; FDA Pregnancy Cate- gory X

DailyMed; DrugBank

entecavir

8:18:32 nucleosides and nucleotides

FDA Pregnancy Category C

DailyMed; DrugBank

epirubicin

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; Drugbank

ergonovine/meth- ylergonovine

76:00 oxytocics

Use is contraindicated during pregnancy because of its uterotonic effects; FDA Preg- nancy Category C

DailyMed; DrugBank; DrugBank

eribulin

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

erlotinib

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

estradiol

68:16:04 estrogens

DailyMed; DrugBank

estramustine

10:00 antineoplastic agents

FDA Pregnancy Category X

DailyMed; Drugbank

estrogen/ progesterone combinations

68:12 contraceptives

DailyMed

estrogens, conjugated

68:16:04 estrogens

DailyMed

estrogens, esterified

68:16:04 estrogens

DailyMed

estropipate

68:16:04 estrogens

DailyMed; DrugBank

etoposide

10:00 antineoplastic agents

IARC Group 1 carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

everolimus

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; Drugbank

exemestane

10:00 antineoplastic agents

FDA Pregnancy Category X

DailyMed; DrugBank

finasteride

92:08 5-alpha reductase inhibitors

Women should not handle crushed or broken finasteride tablets when they are preg- nant or may potentially be pregnant due to potential risk to a male fetus; FDA Preg- nancy Category X

DailyMed; Drugbank

fingolimod

92:20 biologic response modifiers

DailyMed; DrugBank

floxuridine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

fluconazole

8:18.08 azoles

FDA Pregnancy Category C; case reports describe con- genital anomalies in infants exposed in utero to maternal fluconazole (400-800 mg/ day) during most or all of the first trimester, similar to those seen in animal studies

DailyMed; DrugBank

fludarabine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

fluorouracil

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

fluoxymesterone

68:08 androgens

Tumors in mice and rats and possibly humans; FDA Preg- nancy Category X

DailyMed; DrugBank

flutamide

10:00 antineoplastic agents

Indicated only for men; FDA Pregnancy Category D

DailyMed; DrugBank

fosphenytoin

28:12.12 hydantoins

Metabolized to phenytoin; FDA Pregnancy Category D

DailyMed; DrugBank

fulvestrant

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

ganciclovir

8:18:32 nucleosides and nucleotides

FDA Pregnancy Category C

DailyMed; DrugBank

ganirelix

92:40 gonadotropin- eleasing hormone antagonists

FDA Pregnancy Category X

DailyMed

gemcitabine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

gemtuzumab ozogamicin

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

gonadotropin, chorionic

68:18 gonadotropins

Defects of forelimbs and central nervous system and alterations in sex ratio have been reported in laboratory studies; FDA pregnancy Cat- egory C

DailyMed; DrugBank7

goserelin

10:00 antineoplastic agents

FDA Pregnancy Category X

DailyMed; Drugbank

hydroxyurea

10:00 antineoplastic agents

Special warning on handling bottles and capsules

DailyMed; DrugBank

icatibant

92:32 complement inhibitors

FDA Pregnancy Category C; in laboratory studies, prema- ture birth and abortion rates increased at a dose that was less than 1/40th the MRHD and delayed parturition and fetal death occurred at 0.5 and 2-fold, respectively, the MRHD

DailyMed; DrugBank

idarubicin

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

ifosfamide

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

imatinib

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

irinotecan

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

ixabepilone

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

leflunomide

92:36 disease-modifying antirheumatic agents

Teratogenic in laboratory studies at 1/10 HD; marked postnatal survival at 1/100 HD; FDA Pregnancy Cate- gory X; severe liver injury reported in patients; carcino- genicity observed at doses below HD

DailyMed; DrugBank

lenalidomide

92:20 biologic response modulators

Analog of thalidomide; FDA Black box warnings for limb abnormalaties; pregnancy Cat- egory X; in laboratory studies, caused thalidomide-type limb defects in monkey offspring

DailyMed; DrugBank

letrozole

10:00 antineoplastic agents

FDA pregnancy Category X

DailyMed; DrugBank

leuprolide

10:00 antineoplastic agents

FDA Pregnancy Category X

DailyMed; Drugbank

liraglutide recombinant

68:20.06 incretin mimetics

FDA Pregnancy Category C; Black Box warning for thy- roid C-cell tumors, with supporting evidence in lab- oratory studies; also in labo- ratory studies, teratogenic at or below the MRHD.

DailyMed; DrugBank

lomustine

10:00 antineoplastic agents

IARC Group 2A carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

mechloreth- amine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

medroxyproges- terone acetate

68:32 progestins

IARC Group 2B; FDA Preg- nancy Category X

DailyMed; DrugBank

megestrol

10:00 antineoplastic agents

Nursing should be dis- continued if megestrol is required. Women at risk of pregnancy should avoid exposure; FDA Pregnancy Category X

DailyMed; DrugBank

melphalan

10:00 antineoplastic agents

IARC Group 1 carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

mentropins

68:18 gonadotropins

FDA Pregnancy Category X

Drugbank

mercaptopurine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

methotrexate

10:00 antineoplastic agents

FDA Pregnancy Category X

DailyMed; DrugBank

methyltestos- terone

68:08 androgens

FDA Pregnancy Category X

DailyMed; DrugBank

mifepristone

76:00 oxytocics

When given to pregnant women results in termination of pregnancy; FDA Pregnancy Category X

DailyMed; DrugBank

misoprostol

56:28.28 prostaglandins

FDA Pregnancy Category X

DailyMed; DrugBank

mitomycin

10:00 antineoplastic agents

IARC Group 2B; FDA Preg- nancy Category D

DailyMed; DrugBank

mitotane

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

mitoxantrone

10:00 antineoplastic agents

IARC Group 2B; FDA Preg- nancy Category D

DailyMed; DrugBank

mycophenolate mofetil

92:44 immunosuppressive agents

DailyMed; DrugBank

mycophenolic acid

92:44 immunosuppressive agents

DailyMed; DrugBank

nafarelin

68:18 gonadotropins

Note: Given only as nasal spray; no potential for occu- pational exposure; FDA Preg- nancy Category X

DailyMed; DrugBank

nelarabine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

nevirapine

8:18.08.16 nonnucleoside reverse transcriptase inhibitors

DailyMed; DrugBank

nilotinib

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

omacetaxin

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

oxaliplatin

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

oxcarbazepine

28:12:92 anticonvulsants, miscellaneous

DailyMed; Drugbank

oxytocin

76:00 oxytocics

Hazardous only for women in 3rd trimester; FDA Pregnancy Category C

DailyMed; DrugBank

paclitaxel

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

palifermin

84:16 cell stimulants and proliferants

DailyMed; Drugbank

paroxetine

28:16:04:20 selective sero- tonin uptake inhibitors

Increased risk of congenital abnormalities when taken in first trimester; complications in pregnancy when taken in third trimester; FDA Preg- nancy Category D

DailyMed; Drugbank

pazopanib

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

pemetrexed

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

pentetate calcium trisodium

NA

Severe teratogenic effects in laboratory studies in dogs: supplied in ampule which can lead to occupational exposure; FDA Pregnancy Category C

DailyMed

pentostatin

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

phenoxyben- zamine

12:16:04:04 non-selective alpha-andrenergic blocking agents

DailyMed; DrugBank

phenytoin

28:12.12 hydantoins

DailyMed; DrugBank

pipobroman

NA

Drugbank

plerixafor

20:16 hematopoietic agents

Teratogenic in laboratory studies; FDA Pregnancy Cate- gory D

DailyMed; DrugBank

pralatrexate

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

procarbazine

10:00 antineoplastic agents

IARC Group 2A carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

progesterone

68:32 progestins

DailyMed; Drugbank

progestins

68:12 contraceptives

propylthiouracil

68:36.08 antithyroid agents

DailyMed; DrugBank

raloxifene

68:16:12 estrogen ago- nists-antagonists

DailyMed; Drugbank

rasagiline

28:36 antiparkinsonian agents

DailyMed; Drugbank

ribavirin

8:18:32 nucleosides and nucleotides

Teratogenic and embryotoxic effects in several laboratory studies; contraindicated in women who are pregnant and in the male partners of women who are pregnant; FDA Pregnancy Category X

DailyMed; DrugBank

risperidone

28:16:08:04 atypical anti- psychotics

DailyMed; DrugBank

romidepsin

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed

sirolimus

92:44 immunosuppressive agents

DailyMed; DrugBank

sorafenib

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

spironolactone

24:32.20 mineralocorticoid receptor antagonists

FDA Pregnancy Category C; black box warning for tumorogenicity in laboratory studies.

DailyMed; DrugBank

streptozocin

10:00 antineoplastic agents

IARC Group 2B; FDA Preg- nancy Category D

DailyMed; DrugBank

sunitinib

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

tacrolimus

92:44 immunosuppressive agents

Increased risk of lymphomas and other malignancies; reproductive effects seen in laboratory studies below the MRHD; excreted in breast milk; FDA Pregnancy Cate- gory C

DailyMed; DrugBank

tamoxifen

10:00 antineoplastic agents

IARC Group 1 carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

telavancin

8:12:28 glycopeptides

Black Box warning for poten- tial risk to fetus and adverse reproductive outcomes; reduced fetal weights and increased rates of digit and limb malformations in three species at clinical doses; FDA Pregnancy Category C

DailyMed; Drugbank

temozolomide

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

temsirolimus

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

teniposide

10:00 antineoplastic agents

IARC Group 2A carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

testosterone

68:08 androgens

Children should avoid contact with unwashed or unclothed application sites on skin; FDA Pregnancy Category X

DailyMed; DrugBank

thalidomide

92:20 biologic response modulators

FDA Pregnancy Category X

DailyMed; DrugBank

thioguanine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

thiotepa

10:00 antineoplastic agents

IARC Group 1 carcinogen; FDA Pregnancy Category D

DailyMed; DrugBank

topiramate

28:12.92 anticonvulsants, miscellaneous

FDA Pregnancy Category D

DailyMed; DrugBank

topotecan

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

toremifene

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

tretinoin

84:16 cell stimulants and proliferants

Black Box warning for severe birth defects; Special FDA dis- tribution system; FDA Preg- nancy Category X

DailyMed; DrugBank

trimetrexate

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

triptorelin

10:00 antineoplastic agents

FDA Pregnancy Category X

DailyMed

ulipristal

68:12 contraceptives

FDA Pregnancy Category X

DailyMed

uracil mustard

NA

FDA Pregnancy Category D

DrugBank

valganciclovir

8:18:32 nucleosides and nucleotides

FDA Pregnancy Category C

DailyMed; DrugBank

valproate/valproic acid

28:12:92 anticonvulsants, miscellaneous

Black Box warning for terato- genicity; congenital malfor- mations including neural tube defects and others; terato- genic in multiple species; FDA Pregnancy Category D

DailyMed; DailyMed; DrugBank

valrubicin

10:00 antineoplastic agents

FDA Pregnancy Category C

DailyMed; DrugBank

vandetanib

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

vemurafenib

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

vigabatrin

28:12:92 anticonvulsants, miscellaneous

Malformations seen in labora- tory studies below the MRHD; FDA Pregnancy Category C

DailyMed; Drugbank

vinblastine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

vincristine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; Drugbank

vinorelbine

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; DrugBank

voriconazole

8:14.08 azoles

FDA Pregnancy Category D

DailyMed; DrugBank

vorinostat

10:00 antineoplastic agents

FDA Pregnancy Category D

DailyMed; Drugbank

warfarin

20:12.04.08 coumarin derivatives

FDA Pregnancy Category D

DailyMed; DrugBank

zidovudine

8:18:08 antiretroviral agents

IARC Group 2B; FDA Preg- nancy Category C

DailyMed; DrugBank

ziprasidone

28:16:08:04 atypical antipsychotics

Developmental toxicity, including possible terato- genic effects at doses similar to human therapeutic doses; an increase in the number

DailyMed; Drugbank

zoledronic acid

92:24 bone resorption inhibitors

Number of stillbirths increased and survival of neo- nates decreased in laboratory studies at low doses; FDA Pregnancy Category D

DailyMed; DrugBank

zonisamide

28:12:92 anticonvulsants, miscellaneous

Teratogenic in multiple animal species; FDA Preg- nancy Category C

DailyMed; DrugBank